Beschreibung
Overview:
Clonality: Polyclonal
Host: Rabbit
Reactivity:Human
Applications: WB, IHC-p, IF, ELISA
Storage: -20°C for one year
Concentration: 1 mg/ml
Detailed Information:
APAF1 encodes a cytoplasmic protein that initiates apoptosis. This protein (apoptotic peptidase activating factor 1) contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Antibody Production Information:
The antiserum was produced against synthesized peptide derived from human APAF-1-ALT. AA range:289-338
Target:
Target: APAF1-interacting protein
Synonyms: APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19; dJ179L10.2; likely ortholog of mouse monocyte macrophage 19
Supplier: BT-Labs