Bovine Insulin-like Growth Factors 1, IGF-1 ELISA Kit

Overview:

Target Protein: Insulin-like Growth Factors 1 (IGF1)

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.53ng/ml

Detection range: 1-400ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Bovine

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

The Insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV: ITGB3 and ITGA6: ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

IGF1 Information:

UniProt Accession: P07455

Synonyms: IGF 1;IGF1;IGF-I;Insulin-like growth factor I;Somatomedin

References:

• Investigations on Modulating Effect of Vanadium Supplementation on Growth and Metabolism Through Improved Immune Response, Antioxidative Profile and Endocrine Variables in Hariana heifers
• Journal: Biol Trace Elem Res. 2020 Apr;194(2):379-389.
• Meprin A1 subunit beta gene polymorphism is associated with the length of post-partum anestrus interval in Murrah buffaloes
• Journal: Gene. 2022 Jun 15;827:146456.
• Comparative effect of zinc supplementation by hydroxy and inorganic sources on nutrient utilisation, mineral balance, growth performance and growth biomarkers in pre-ruminant calves
• Journal: Arch Anim Nutr. 2021 Dec;75(6):435-449.
• Influence of astaxanthin supplementation on attainment of puberty and lipid peroxidation in Sahiwal and Karan Fries (Holstein × Tharparkar) heifers during summer season
• Journal: Sunil Kumar & S. V. Singh (2020) Influence of astaxanthin supplementation on attainment of puberty and lipid peroxidation in Sahiwal and Karan Fries (Holstein × Tharparkar) heifers during summer season, Biological Rhythm Research, 51:1, 15-28
• Protein Supplementation during Mid-Gestation Alters the Amino Acid Patterns, Hepatic Metabolism, and Maternal Skeletal Muscle Turnover of Pregnant Zebu Beef Cows
• Journal: Animals (Basel). 2022 Dec 16;12(24):3567.

Supplier: BT-Labs