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Bovine Insulin-like Growth Factors 1, IGF-1 ELISA Kit

ab 495,00 €

(1 Bausatz/-sätze = 495,00 €)
zzgl. MwSt. zzgl. Versand

Artikelnummer: E0016Bo


Beschreibung

Overview:

Target Protein: Insulin-like Growth Factors 1 (IGF1)

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 0.53ng/ml

Detection range: 1-400ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Bovine


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

The Insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV: ITGB3 and ITGA6: ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).


IGF1 Information:

UniProt Accession: P07455

Synonyms: IGF 1;IGF1;IGF-I;Insulin-like growth factor I;Somatomedin


References:


Supplier: BT-Labs