• 0941 948228
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  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

CD40 Monoclonal Antibody

ab 380,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: BT-MCA0305


Beschreibung

Overview:

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: IF, ICC, ELISA

Storage: -20°C for one year

Concentration: 1 mg/ml


Detailed Information:

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG).


Antibody Production Information:

Purified recombinant fragment of CD40 expressed in E. Coli.


Target:

Target: CD40

Synonyms: CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40


Supplier: BT-Labs