• 0941 948228
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  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

Factor VIII Monoclonal Antibody

ab 380,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: BT-MCA0524


Beschreibung

Overview:

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB, ELISA

Storage: -20°C for one year

Concentration: 1 mg/ml


Detailed Information:

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.


Antibody Production Information:

Purified recombinant fragment of Factor VIII expressed in E. Coli.


Target:

Target: Factor VIII

Synonyms: F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component


Supplier: BT-Labs