Human Angiotensin Converting Enzyme 2, ACE2 ELISA Kit

Overview:

Target Protein: Angiotensin Converting Enzyme 2, ACE2

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.021ng/ml

Detection range: 0.05-20ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed: 27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid Peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed: 10969042, PubMed: 10924499, PubMed: 11815627, PubMed: 19021774, PubMed: 14504186). Also removes the C-terminal residue from three other vasoactive Peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed: 10969042, PubMed: 11815627). Also cleaves other biological Peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed: 11815627, PubMed: 27217402, PubMed: 28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed: 18424768, PubMed: 19185582). [Isoform 2]: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.

ACE2 Information:

UniProt Accession: Q9BYF1

Synonyms: ACE 2;ACE2;ACEH;ACE-related carboxypeptidase;Angiotensin-converting enzyme 2;Angiotensin-converting enzyme homolog;Angiotensin-converting enzyme-related carboxypeptidase;Metalloprotease MPROT15;Processed angiotensin-converting enzyme 2;

References:

• HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism Journal: J Headache Pain. 2021 Aug 12;22(1):94
• Assessment of the levels of some prognostic biomolecules (galectins, ACE2, SCUBE1/2/3) in COVID-19 patients Journal: Future Microbiol. 2023 Nov 1.
• Assessment of Liver Regeneration in Patients Who Have Undergone Living Donor Hepatectomy for Living Donor Liver Transplantation Journal: Vaccines (Basel). 2023 Jan 21;11(2):244.
• Design, DFT and molecular doping studies of metal complexes as a neurotransmitter modulator of autism spectrum disease in preschool children Journal: Journal of Molecular Structure,Volume 1290,2023,135875

Supplier: BT-Labs