Beschreibung
Overview:
Target Protein: Apelin, APLN
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 3.47ng/L
Detection range: 7-1500ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Endogenous ligand for the apelin receptor (APLNR) (PubMed: 10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed: 11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed: 11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed: 11090199).
APLN Information:
UniProt Accession: Q9ULZ1
Synonyms: Apelin;Apelin-13;Apelin-28;Apelin-31;Apelin-36;APJ endogenous ligand;APLN
References:
- Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial Journal: Br J Nutr. 2018 Feb;119(4):398-406.
- Association of apelin levels in overweight-obese children with pubertal development, but not with insulin sensitivity: 6.5 years follow up evaluation Journal: Endocr Res. 2020 Nov;45(4):233-240.
- Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease Journal: J Res Med Sci. 2017 May 30;22:70.
- Correlation of serum apelin level with carotid intima-media thickness and insulin resistance in a sample of Egyptian patients with type 2 diabetes mellitus Journal: J Res Med Sci. 2022 Feb 18;27:13.
- Effects of synbiotic supplementation on metabolic parameters and apelin in women with polycystic ovary syndrome: a randomised double-blind placebo-controlled trial - Corrigendum Journal: Br J Nutr. 2020 Aug 28;124(4):479.
Supplier: BT-Labs