Human Brain Derived Neurotrophic Factor, BDNF ELISA Kit

Overview:

Target Protein: BDNF, Brain Derived Neurotrophic Factor

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.023ng/ml

Detection range: 0.05-10ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed: 11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed: 24908487, PubMed: 29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).

BDNF Information:

UniProt Accession: P23560

Synonyms: Abrineurin;BDNF;BDNF precursor form;Brain-derived neurotrophic factor;ProBDNF

References:

• Zinc supplementation does not influence serum levels of VEGF, BDNF, and NGF in diabetic retinopathy patients: a randomized controlled clinical trial
• Journal: Nutr Neurosci. 2019 Oct;22(10):718-724.
• Relationship between hedonic hunger and serum levels of insulin, leptin and BDNF in the Iranian population
• Journal: Physiol Behav. 2019 Feb 1;199:84-87.
• Assessment of peripheral biomarkers potentially involved in episodic and chronic migraine: a case-control study with a focus on NGF, BDNF, VEGF, and PGE2.
• Journal: J Headache Pain. 2022 Jan 6;23(1):3.
• A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway
• Journal: J Psychiatr Res. 2021 Oct;142:160-166.
• Can the Imbalance between Neurotrophic and Apoptotic Proteins Be the "Beware the Ides of March" for Unaffected Relatives of Schizophrenia Patients?
• Journal: Mol Neurobiol. 2022 Dec;59(12):7413-7422.
• Changes in serum levels of brain-derived neurotrophic factor with electroconvulsive therapy and pharmacotherapy and its clinical correlates in male schizophrenia patients
• Journal: Acta Neuropsychiatr. 2022 Apr;34(2):99-105.
• Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals
• Journal: Sci Rep. 2023 Apr 29;13(1):7040.
• Exploring the association between depression, suicidality and serum neurotrophin levels in adolescents
• Journal: Int J Psychiatry Clin Pract. 2020 Jun;24(2):143-150.
• BDNF, GDNF, NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia
• Journal: BMC Psychiatry. 2021 Nov 11;21(1):562
• Long-lasting cognitive effects of COVID-19: is there a role of BDNF?
• Journal: Eur Arch Psychiatry Clin Neurosci. 2023 Sep;273(6):1339-1347.
• Serum brain-derived neurotrophic factor and macular perfusion in type 2 diabetes mellitus using optical coherence tomography angiography
• Journal: Taiwan Journal of Ophthalmology, March 21, 2023.
• Acute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjects
• Journal: Sleep Biol. Rhythms 20, 73–79 (2022).
• Clinical utility of serum brain-derived neurotrophic factor levels and its gene polymorphism Val66Met in diabetic retinopathy patients with type 2 diabetes mellitus
• Journal: JRAM 2021; 2(1): 72-79
• Brain-derived neurotrophic factor (BDNF) is increased by omega-3 fatty acids in coronary artery disease: a randomized, double-blind, placebo-controlled
• Journal: J Nutr Sci & Diet. 2016;2(1):2-8.

Supplier: BT-Labs