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  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

Human Caspase 3, CASP3 ELISA Kit

ab 495,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: E4804Hu



Target Protein: Caspase 3, CASP3

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.027ng/ml

Detection range: 0.05-20ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed: 7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed: 7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed: 7596430). Involved in the cleavage of huntingtin (PubMed: 8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed: 21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 23152800).

CASP3 Information:

UniProt Accession: P42574

Synonyms: Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;Protein Yama;SCA-1;SREBP cleavage activity 1


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Supplier: BT-Labs