Beschreibung
Overview:
Target Protein: Cd163 Antigen, CD63
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 0.052ng/ml
Detection range: 0.1-30ng/ml
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
CD63 Information:
UniProt Accession: P08962
Synonyms: CD 63;CD antigen CD63;CD63;CD63 antigen;Granulophysin;LAMP-3;Lysosomal-associated membrane protein 3;Melanoma-associated antigen ME491;Ocular melanoma-associated antigen;OMA81H;Tetraspanin-30;Tspan-30
Supplier: BT-Labs