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  • Sichere Bezahlung
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  • Hohe Qualität
  • info@davids-bio.com

Human Chaperonin 10, CPN10 ELISA Kit

ab 495,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: E0673Hu


Beschreibung

Overview:

Target Protein: Chaperonin 10, HSPE1

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 0.026ng/ml

Detection range: 0.05-20ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed: 7912672, PubMed: 1346131, PubMed: 11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).


HSPE1 Information:

UniProt Accession: P61604

Synonyms: 10 kDa chaperonin;10 kDa heat shock protein, mitochondrial;Chaperonin 10;CPN10;Early-pregnancy factor;EPF;Hsp10;HSPE 1;HSPE1;


Supplier: BT-Labs