Human Chitinase-3-like Protein 1, CHI3L1 ELISA Kit

Overview:

Target Protein: Chitinase-3-Like Protein 1, CHI3L1

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.61ng/ml

Detection range: 1-400ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

CHI3L1 Information:

UniProt Accession: P36222

Synonyms: 39 kDa synovial protein;Cartilage glycoprotein 39;CGP-39;CHI3L1;Chitinase-3-like protein 1;GP-39;hCGP-39;YKL-40

References:

• Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer Journal: Int J Gynaecol Obstet. 2021 Dec;155(3):417-424.
• The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma Journal: Hum Exp Toxicol. 2021 Nov;40(11):1817-1824.
• Evaluation of serum YKL-40 level among clinical risk scores for early mortality in acute pulmonary thromboembolism Journal: Clin Biochem. 2022 Oct;108:20-26.

Supplier: BT-Labs