• 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com
  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

Human Complement Factor H, CFH ELISA Kit

ab 495,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: E0324Hu


Beschreibung

Overview:

Target Protein: Complement Factor H, CFH

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 4.88ng/ml

Detection range: 10-3000ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed: 21285368, PubMed: 25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop (PubMed: 19503104). As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b (PubMed: 18252712, PubMed: 28671664). In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed (PubMed: 9558116, PubMed: 20008295).


CFH Information:

UniProt Accession: P08603

Synonyms: CFH;Complement factor H;H factor 1


Supplier: BT-Labs