Human Cyclin-dependent Kinase 4, CDK-4 ELISA Kit
ab 495,00 €
Artikelnummer: E0870Hu
Beschreibung
Overview:
Target Protein: Cyclin-Dependent Kinase 4, CDK4
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 0.022ng/ml
Detection range: 0.05-20ng/ml
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
CDK4 Information:
UniProt Accession: P11802
Synonyms: CDK 4;CDK4;Cell division protein kinase 4;Cyclin-dependent kinase 4;PSK-J3
Supplier: BT-Labs