Human DNA Repair Protein Rad51 Homolog 1, RAD51 ELISA Kit

Overview:

Target Protein: Dna Repair Protein Rad51 Homolog 1, RAD51

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.11ng/ml

Detection range: 0.2-70ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed: 28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed: 26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed: 26253028).

RAD51 Information:

UniProt Accession: Q06609

Synonyms: DNA repair protein RAD51 homolog 1;hRAD51;HsRAD51;RAD51;RAD51 homolog A

Supplier: BT-Labs