Beschreibung
Overview:
Target Protein: E-Cadherin, CDH1
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 0.52ng/ml
Detection range: 1-300ng/ml
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cadherins are calcium-dependent cell adhesion proteins (PubMed: 11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed: 11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
CDH1 Information:
UniProt Accession: P12830
Synonyms: Cadherin-1;CAM 120/80;CD antigen CD324;CDH 1;CDH1;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;E-cadherin;Epithelial cadherin;Uvomorulin
Supplier: BT-Labs