Human G1/S-specific Cyclin-D1, CYCLIN-D1 ELISA Kit

Overview:

Target Protein: G1/S-Specific Cyclin-D1, CCND1

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.052ng/ml

Detection range: 0.1-40ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

CCND1 Information:

UniProt Accession: P24385

Synonyms: B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;CCND 1;CCND1;G1/S-specific cyclin-D1;PRAD1 oncogene

Supplier: BT-Labs