Human Galectin-3, ELISA Kit

Overview:

Target Protein: Galectin-3, LGALS3

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 2.49pg/ml

Detection range: 5-2000pg/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.

LGALS3 Information:

UniProt Accession: P17931

Synonyms: 35 kDa lectin;Carbohydrate-binding protein 35;CBP 35;Gal-3;Galactose-specific lectin 3;Galactoside-binding protein;GALBP;Galectin-3;IgE-binding protein;L-31;Laminin-binding protein;Lectin L-29;LGALS 3;LGALS3;Mac-2 antigen

References:

• Galectin-3, a potential predictor and contributor of placenta accreta spectrum pathogenesis by inducing local vascular cell adhesion molecule-1 expression: A longitudinal study Journal: Bulletin of Egyptian Society for Physiological Sciences, Volume 43, Issue 4, October 2023, Page 266-277
• Assessment of the relationship between galectin-3 and ejection fraction and functional capacity in the patients with compensated systolic heart failure Journal: Int Cardiovasc Res J. 2014 Dec;8(4):143-7.
• Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents Journal: BMJ Open Diabetes Res Care. 2021 Apr;9(1):e001894.
• ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia Journal: J Obstet Gynaecol. 2022 Jul;42(5):1023-1029.
• Galectin-3 levels in school aged children with autism spectrum disorder Journal: Int J Dev Disabil. 2022 Dec 1;69(5):757-761.
• The impact of zinc supplementation on galectin-3 and metabolic markers in diabetic patients on hemodialysis: A randomized, double-blind, placebo-controlled trial Journal: J Diabetes Metab Disord. 2022 May 14;21(1):743-750.
• Elevated Serum Galectin-1 and Galectin-3 Levels in Children With Specific Learning Disorder: A Case Control Study Journal: Psychiatry Investig. 2023 Jul;20(7):609-615.
• Increased maternal serum aquaporin 9 levels in pregnancies complicated with gestational diabetes mellitus Journal: J Matern Fetal Neonatal Med. 2022 Jan;35(1):18-23.
• ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia Journal: J Obstet Gynaecol. 2022 Jul;42(5):1023-1029.
• Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls Journal: Abbasi Natajomrani R, Qujeq D, Hosseini V , Hajihosseini R . Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls. J Kermanshah Univ Med Sci. 2020;24(4):e107028.
• Assessment of the levels of some prognostic biomolecules (galectins, ACE2, SCUBE1/2/3) in COVID-19 patients Journal: Future Microbiol. 2023 Nov 1.

Supplier: BT-Labs