Human Growth Differentiation Factor 15, GDF15 ELISA Kit

Overview:

Target Protein: Growth Differentiation Factor 15, GDF15

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 5.57ng/L

Detection range: 10-3000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed: 28953886, PubMed: 28846097, PubMed: 28846098, PubMed: 28846099, PubMed: 23468844, PubMed: 29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed: 28953886, PubMed: 28846097, PubMed: 28846098, PubMed: 28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed: 28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

GDF15 Information:

UniProt Accession: Q99988

Synonyms: GDF 15;GDF15;GDF-15;Growth/differentiation factor 15;Macrophage inhibitory cytokine 1;MIC-1;NAG-1;NRG-1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental bone morphogenetic protein;Placental TGF-beta;Prostate differentiation factor;

References:

• Growth differentiation factor 15: an emerging diagnostic biomarker of liver fibrosis in chronic hepatitis C patients Journal: Egypt Liver J. 2021;11(1):6.
• The association between growth differentiation factor-15, erythroferrone, and iron status in thalassemic patients Journal: Pediatr Res. 2023 Jul 18.

Supplier: BT-Labs