Human Haptoglobin/Zonulin, HPT/HP ELISA Kit

Overview:

Target Protein: Haptoglobin/Zonulin

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 1.09ug/ml

Detection range: 2-600ug/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

HP Information:

UniProt Accession: P00738

Synonyms: Haptoglobin;Haptoglobin alpha chain;Haptoglobin beta chain;HP;Zonulin

Supplier: BT-Labs