Human Hepcidin, HEPC ELISA Kit

Overview:

Target Protein: Hepcidin, HEPC

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 5.12pg/ml

Detection range: 10-4000pg/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed: 22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed: 11113131, PubMed: 11034317).

HEPC Information:

UniProt Accession: P81172

Synonyms: HEPC;Hepc20;Hepc25;Hepcidin;Hepcidin-20;Hepcidin-25;LEAP-1;Liver-expressed antimicrobial Peptide 1;PLTR;Putative liver tumor regressor

References:

• Evaluation of serum hepcidin and iron levels in patients with PCOS: a case-control study Journal: J Endocrinol Invest. 2017 Jul;40(7):779-784.
• The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19 Journal: Int J Lab Hematol. 2021 Jul;43 Suppl 1(Suppl 1):142-151.

Supplier: BT-Labs