Human Histone Deacetylase 6, HDAC6 ELISA Kit

Overview:

Target Protein: Histone Deacetylase 6, HDAC6

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.31ng/ml

Detection range: 0.5-40ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed: 10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed: 10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed: 10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed: 12024216, PubMed: 20308065). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed: 30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed: 24413532). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed: 17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed: 17846173).

HDAC6 Information:

UniProt Accession: Q9UBN7

Synonyms: HD6;HDAC 6;HDAC6;Histone deacetylase 6;Tubulin-lysine deacetylase HDAC6

Supplier: BT-Labs