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Human Hypoxia-inducible Factor 1Α, HIF-1A ELISA Kit

ab 495,00 €

(1 Bausatz/-sätze = 495,00 €)
zzgl. MwSt. zzgl. Versand

Artikelnummer: E0422Hu


Beschreibung

Overview:

Target Protein: Hypoxia-Inducible Factor 1 alpha, HIF1A

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 0.01ng/ml

Detection range: 0.05-15ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia. (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, is required for induction of glycolysis in monocytes and the consequent proinflammatory state (PubMed: 32697943). In monocytes, induces expression of ACE2 and cytokines such as IL1B, TNF, IL6, and interferons (PubMed: 32697943). Promotes human coronavirus SARS-CoV-2 replication and monocyte inflammatory response (PubMed: 32697943).


HIF1A Information:

UniProt Accession: Q16665

Synonyms: ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;bHLHe78;Class E basic helix-loop-helix protein 78;HIF 1A;HIF1A;HIF1-alpha;HIF-1-alpha;Hypoxia-inducible factor 1-alpha;Member of PAS protein 1;PAS domain-containing protein 8


References:


Supplier: BT-Labs