Human Insulin-like Growth Factors 1, IGF-1 ELISA Kit

Overview:

Target Protein: Insulin-like Growth Factors 1 (IGF1)

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.058ng/ml

Detection range: 0.1-40ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

The Insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed: 21076856, PubMed: 24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed: 19578119, PubMed: 22351760, PubMed: 23696648, PubMed: 23243309).

IGF1 Information:

UniProt Accession: P05019

Synonyms: IGF 1;IGF1;IGF-I;Insulin-like growth factor I;Mechano growth factor;MGF;Somatomedin-C

References:

• Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: the Vitamin D Pregnant Mother (VDPM) cohort studyJournal: BMC Pregnancy Childbirth. 2022 Sep 7;22(1):690
• Evaluation of the relationship between pain inflammation due to dental caries and growth parameters in preschool childrenJournal: Clin Oral Investig. 2023 Jul;27(7):3721-3730.
• Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severityJournal: Virol J. 2023 May 15;20(1):94.

Supplier: BT-Labs