Human Interferon Regulatory Factor 8, IRF8 ELISA Kit

Overview:

Target Protein: Interferon Regulatory Factor 8, IRF8

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 2.44ng/L

Detection range: 5-1000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed: 25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed: 29434592).

IRF8 Information:

UniProt Accession: Q02556

Synonyms: H-ICSBP;ICSBP;Interferon consensus sequence-binding protein;Interferon regulatory factor 8;IRF 8;IRF8;IRF-8

Supplier: BT-Labs