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  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

Human Interleukin 11, IL-11 ELISA Kit

ab 495,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: E0101Hu


Beschreibung

Overview:

Target Protein: Interleukin 11, IL11

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 0.31ng/L

Detection range: 0.5-300ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed: 12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed: 30279168).


IL11 Information:

UniProt Accession: P20809

Synonyms: Adipogenesis inhibitory factor;AGIF;IL 11;IL11;IL-11;Interleukin-11;Oprelvekin

References:



Supplier: BT-Labs