Beschreibung
Overview:
Target Protein: Interleukin 11, IL11
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 0.31ng/L
Detection range: 0.5-300ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed: 12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed: 30279168).
IL11 Information:
UniProt Accession: P20809
Synonyms: Adipogenesis inhibitory factor;AGIF;IL 11;IL11;IL-11;Interleukin-11;Oprelvekin
References:
- Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome Journal: Iran J Allergy Asthma Immunol. 2019 Feb;18(1):91-99.
- The Value of Interleukin-17A as a Prognostic Indicator in COVID-19 Patients Journal: Jundishapur J Microbiol. 2022;15(11):e130316.
Supplier: BT-Labs