Beschreibung
Overview:
Target Protein: Interleukin 16, IL16
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 1.47ng/L
Detection range: 3-900ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. [Isoform 1]: may act as a scaffolding protein that anchors ion Channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
IL16 Information:
UniProt Accession: Q14005
Synonyms: IL 16;IL16;IL-16;LCF;Lymphocyte chemoattractant factor;Pro-interleukin-16 Interleukin-16
Supplier: BT-Labs