Beschreibung
Overview:
Target Protein: Interleukin 17C, IL17C
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 15.49ng/L
Detection range: 30-9000ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial Peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial Peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
IL17C Information:
UniProt Accession: Q9P0M4
Synonyms: Cytokine CX2;IL 17C;IL17C;IL-17C;Interleukin-17C
Supplier: BT-Labs