Human Interleukin 18, IL-18 ELISA Kit

Overview:

Target Protein: Interleukin 18, IL18

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.2ng/L

Detection range: 0.5-100ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed: 14528293, PubMed: 25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed: 10653850).

IL18 Information:

UniProt Accession: Q14116

Synonyms: Iboctadekin;IFN-gamma-inducing factor;IL 18;IL-1 gamma;IL18;IL-18;Interferon gamma-inducing factor;Interleukin-1 gamma;Interleukin-18;

References:

• Apolipoprotein A2? 265 T> C polymorphism interacts with dietary fatty acids intake to modulate inflammation in type 2 diabetes mellitus patients Journal: Nutrition. 2017 May;37:86-91.
• Predictive Values of Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin for Delayed Graft Function Diagnosis in Kidney Transplantation Journal: Iran J Pathol. 2016 Fall;11(4):391-398.
• Effect of Hypertonic Saline 5% on Early Graft Function and Urinary Interleukin 18 and Neutrophil Gelatinase-Associated Lipocalin in Deceased-Donor Kidney Transplantation Journal: Iran J Pharm Res. 2017 Fall;16(4):1583-1592.
• Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study Journal: Eur J Pediatr. 2022 Aug;181(8):3093-3101.
• Interleukin-18 serum level before and after intralesional immunotherapy with tuberculin purified protein derivative in patients with cutaneous and genital warts Journal: J Cosmet Dermatol. 2022 Dec;21(12):7035-7042.
• Efficacy of multiple Biomarkers: NGAL, KIM1, Cystatin C and IL18 in predicting pregnancy related acute kidney injury Journal: Pak J Med Sci. 2023 Jan-Feb;39(1):34-40.
• The effect of magnesium sulfate on gene expression and serum level of inflammatory cytokines in coronary artery disease patients Journal: Inflammopharmacology. 2023 Oct;31(5):2421-2430.
• Interleukin-40 is a promising biomarker associated with type 2 diabetes mellitus risk Journal: Immunol Lett. 2023 Feb;254:1-5.
• The effect of magnesium sulfate on gene expression and serum level of inflammatory cytokines in coronary artery disease patients Journal: Inflammopharmacology. 2023 Oct;31(5):2421-2430.
• A novel signature of interleukins 36α, 37, 38, 39 and 40 in ankylosing spondylitis Journal: Cytokine. 2023 Feb;162:156117.

Supplier: BT-Labs