Beschreibung
Overview:
Target Protein: Interleukin 21, IL21
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 2.46ng/L
Detection range: 5-1500ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (PubMed: 11081504, PubMed: 15178704). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
IL21 Information:
UniProt Accession: Q9HBE4
Synonyms: IL 21;IL21;IL-21;Interleukin-21;Za11
Supplier: BT-Labs