Beschreibung
Overview:
Target Protein: Interleukin 28A, IL28A
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 9.51ng/L
Detection range: 20-3800ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
IL28A Information:
UniProt Accession: Q8IZJ0
Synonyms: Cytokine Zcyto20;IFN-lambda-2;IL 28A;IL28A;IL-28A;Interferon lambda-2;Interleukin-28A
Supplier: BT-Labs