Beschreibung
Overview:
Target Protein: Interleukin 29, IL29
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 3.42ng/L
Detection range: 6-1800ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
IL29 Information:
UniProt Accession: Q8IU54
Synonyms: Cytokine Zcyto21;IFN-lambda-1;IL 29;IL29;IL-29;Interferon lambda-1;Interleukin-29
References:
- Transcriptome profiling reveals differential expression of interferon family induced by dengue virus 2 in human endothelial cells on tissue culture plastic and polyacrylamide hydrogel Journal: J Med Virol. 2016 Jul;88(7):1137-51.
Supplier: BT-Labs