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  • Sichere Bezahlung
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  • Hohe Qualität
  • info@davids-bio.com

Human Interleukin 33, IL-33 ELISA Kit

ab 495,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: E0044Hu


Beschreibung

Overview:

Target Protein: Interleukin 33, IL33

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -


Sensitivity: 5.36ng/L

Detection range: 10-2000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human


Storage: 2 - 8°C

Assay Time: 1:30 h


Detailed Information:

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed: 16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed: 17853410, PubMed: 18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed: 21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed: 18787100).


IL33 Information:

UniProt Accession: O95760

Synonyms: 109-270;95-270;99-270;IL 33;IL-1F11;IL33;IL-33;Interleukin-1 family member 11;Interleukin-33;NF-HEV;Nuclear factor from high endothelial venules

References:


Supplier: BT-Labs