Beschreibung
Overview:
Target Protein: Interleukin 33, IL33
Size: 48T, 96T
Assay Type: Sandwich
One-Step: -
Sensitivity: 5.36ng/L
Detection range: 10-2000ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Human
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed: 16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed: 17853410, PubMed: 18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed: 21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed: 18787100).
IL33 Information:
UniProt Accession: O95760
Synonyms: 109-270;95-270;99-270;IL 33;IL-1F11;IL33;IL-33;Interleukin-1 family member 11;Interleukin-33;NF-HEV;Nuclear factor from high endothelial venules
References:
- Evaluation of periodontal status and cytokine response in children with familial Mediterranean fever or systemic juvenile idiopathic arthritis Journal: Clin Oral Investig. 2023 Mar;27(3):1159-1166.
- Association of Interleukin-33 with Recurrent Pregnancy Loss in Egyptian Women Journal: Eur Cytokine Netw. 2022 Jun 1;33(2):13-18
Supplier: BT-Labs