Human Interleukin 4, IL-4 ELISA Kit

Overview:

Target Protein: Interleukin 4, IL4

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 2.53ng/L

Detection range: 5-1000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Participates in at least several B-cell activation processes as well as of other cell types (PubMed: 3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).

IL4 Information:

UniProt Accession: P05112

Synonyms: B-cell stimulatory factor 1;Binetrakin;BSF-1;IL 4;IL4;IL-4;Interleukin-4;Lymphocyte stimulatory factor 1;Pitrakinra;

References:

• Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP)
• Journal: Clin Exp Immunol. 2014 May;176(2):291-300
• Assessment of neutralizing interleukin-4 effect on CD133 gene expression in colon cancer cell line
• Journal: Cytokine. 2017 Sep;97:66-72.

Supplier: BT-Labs