Human Myelin Basic Protein, MBP ELISA Kit

Overview:

Target Protein: Myelin Basic Protein, MBP

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 32.27ng/L

Detection range: 50-6000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

MBP Information:

UniProt Accession: P02686

Synonyms: MBP;Myelin A1 protein;Myelin basic protein;Myelin membrane encephalitogenic protein

Supplier: BT-Labs