Human Stem Cell Factor/Mast Cell Growth Factor, SCF/MGF ELISA Kit

Overview:

Target Protein: Stem Cell Factor/Mast Cell Growth Factor, KITLG

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 2.52pg/ml

Detection range: 5-1800pg/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

KITLG Information:

UniProt Accession: P21583

Synonyms: c-Kit ligand;Kit ligand;KITLG;Mast cell growth factor;MGF;SCF;sKITLG;Soluble KIT ligand;Stem cell factor;

References:

• The Effect of Follicular Fluid Stem Cell Factor on Clinical Pregnancy in PCOS Patients Journal: Annals of the Romanian Society for Cell Biology, 25(6), 12361–12367.

Supplier: BT-Labs