Human T-lymphocyte Activation Antigen Cd86, CD86 ELISA Kit

Overview:

Target Protein: T-Lymphocyte Activation Antigen CD86, CD86

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.05ng/ml

Detection range: 0.1-40.ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed: 7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). [Isoform 2]: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.

CD86 Information:

UniProt Accession: P42081

Synonyms: Activation B7-2 antigen;B70;BU63;CD 86;CD antigen CD86;CD86;CTLA-4 counter-receptor B7.2;FUN-1;T-lymphocyte activation antigen CD86;

Supplier: BT-Labs