Human Vascular Endothelial Cell Growth Factor A, VEGF-A ELISA Kit

Overview:

Target Protein: Vascular Endothelial Cell Growth Factor A, VEGFA

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 1.52ng/L

Detection range: 3-900ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).

VEGFA Information:

UniProt Accession: P15692

Synonyms: Vascular endothelial growth factor A;Vascular permeability factor;VEGF A;VEGFA;VEGF-A;VPF

References:

• Bevacizumab Inhibits Angiogenic Cytokines in Head and Neck Squamous Cell Carcinoma: From Gene to the Protein
• Journal: Int J Hematol Oncol Stem Cell Res. 2018 Apr 1;12(2):136-141.
• Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia
• Journal: J Mol Neurosci. 2015 Aug;56(4):898-906.
• Acute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjects
• Journal: Sleep Biol. Rhythms 20, 73–79 (2022).

Supplier: BT-Labs