IGF-IR Monoclonal Antibody
ab 380,00 €
Applications: WB, IHC-p, ELISA
Storage: -20°C for one year
Concentration: 1 mg/ml
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Antibody Production Information:
Purified recombinant fragment of IGF-IR expressed in E. Coli.
Synonyms: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221