• 0941 948228
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  • 0941 948228
  • Sichere Bezahlung
  • Schneller Versand
  • Hohe Qualität
  • info@davids-bio.com

LEDGF Monoclonal Antibody

ab 380,00 €

zzgl. MwSt. zzgl. Versand

Artikelnummer: BT-MCA0843


Beschreibung

Overview:

Clonality: Monoclonal

Host: Mouse

Reactivity:Human, Rat, Monkey

Applications: WB, IHC-p, IF, ICC, ELISA

Storage: -20°C for one year

Concentration: 1 mg/ml


Detailed Information:

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,domain:Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).,function:Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator.


Antibody Production Information:

Purified recombinant fragment of human LEDGF expressed in E. Coli.


Target:

Target: LEDGF

PSIP1; DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52


Supplier: BT-Labs