Beschreibung
Overview:
Target Protein: Interleukin 1beta
Size: 48T, 96T
Assay Type: Sandwich
One-Step: +
Sensitivity: 9.12ng/L
Detection range: 20-4500ng/L
Sample type: Serum, plasma, cell culture supernates
Reactive with: Mouse
Storage: 2 - 8°C
Assay Time: 1:30 h
Detailed Information:
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.
Interleukin 1beta Information:
UniProt Accession: P10749
Synonyms: IL 1B;IL 1beta;IL-1 beta;IL1B;Interleukin-1 beta
References:
- Dimethyl fumarate effects on paraquat-induced hepatotoxicity in mice via anti-oxidative, anti-inflammatory, and anti-apoptotic activities: Maryam Kavianinia, Hadi Kalantar, ..., Mohammad Javad Khodayar; Scientific reports | 2025 Jan 31 | 39890857
- CD36 inhibition corrects lipid-FetuinA mediated insulin secretory defects by preventing intracellular lipid accumulation and inflammation in the pancreatic beta cells: Samanwita Mandal, Snehasish Nag, ..., Rakesh Kundu; Biochimica et biophysica acta. Molecular … | 2024 Dec 06 | 39561856
- Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation: Shahrzad Molavinia, Mehrad Nikravesh, ..., Mohammad Javad Khodayar; Neurochemical research | 2024 Jan 15 | 37864024
- Toxicity evaluation of indocyanine green mediated photodynamic therapy: Turp Isil, Kara Ozlem, ..., Kocyigit Abdurrahim; Photodiagnosis and photodynamic therapy | 2023 Dec 25 | 37595656
- Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice: Saima Khatoon, Nidhi Bharal Agarwal, ..., Ozair Alam; Frontiers in neurology | 2021 Mar 31 | 34354662
Supplier: BT-Labs