Beschreibung
Overview:
Clonality: Polyclonal
Host: Rabbit
Reactivity:Human, Mouse, Rat
Applications: IHC-p, ELISA
Storage: -20°C for one year
Concentration: 1 mg/ml
Detailed Information:
NPHS1 encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. NPHS1 is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Antibody Production Information:
The antiserum was produced against synthesized peptide derived from human Nephrin. AA range:843-892
Target:
Target: Nephrin
Synonyms: NPHS1; NPHN; Nephrin; Renal glomerulus-specific cell adhesion receptor
Supplier:
BT-Labs