Rat Brain Derived Neurotrophic Facor, BDNF ELISA Kit

Overview:

Target Protein: Brain Derived Neurotrophic Facor, BDNF

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.01ng/ml

Detection range: 0.05-10ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Rat

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity). [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.

BDNF Information:

UniProt Accession: P23363

Synonyms: BDNF;BDNF precursor form;Brain-derived neurotrophic factor;ProBDNF

References:

• Evaluation of brain-derived neurotrophic factor in diabetic rats
• Journal: Neurol Res. 2015 Mar;37(3):217-22.
• Hippocampal BDNF content in response to short- and long-term exercise
• Journal: Neurol Sci. 2015 Jul;36(7):1163-6.
• The role of pre-pubertal training history on hippocampal neurotrophic factors and glucocorticoid receptor protein levels in adult male rats
• Journal: Neurosci Lett. 2021 May 1;752:135834.
• Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats
• Journal: J Chem Neuroanat. 2022 Nov;125:102143.

Supplier: BT-Labs