Rat Caspase 3, CASP3 ELISA Kit

Overview:

Target Protein: Caspase 3, CASP3

Size: 48T, 96T

Assay Type: Sandwich

One-Step: -

Sensitivity: 0.02ng/ml

Detection range: 0.05-10ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Rat

Storage: 2 - 8°C

Assay Time: 1:30 h

Detailed Information:

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress.

CASP3 Information:

UniProt Accession: P55213

Synonyms: Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;IRP;LICE;Protein Yama;SCA-1;SREBP cleavage activity 1

References:

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• L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis Journal: J Appl Toxicol. 2023 Nov;43(11):1667-1675.
• Dapagliflozin/Hesperidin Combination Mitigates Lipopolysaccharide-Induced Alzheimer’s Disease in Rats Journal: Pharmaceuticals 2023, 16, 1370.
• Mitoquinone Alleviates Donation after Cardiac Death Kidney Injury during Hypothermic Machine Perfusion in Rat Model Journal: Int J Mol Sci. 2023 Sep 30;24(19):14772.
• Evaluation of the effectiveness of oxytocin and enalapril in the prevention of epidural fibrosis developed after laminectomy in rats Journal: Injury. 2023 Jul;54(7):110793.
• Prophylactic and Therapeutic Efficacy of Boric Acid on Lipopolysaccharide-Induced Liver and Kidney Inflammation in Rats Journal: Biol Trace Elem Res. 2023 Nov 1.
• Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats Journal: Neurol Res. 2023 May;45(5):472-487.
• Investigation of the Gastroprotective Effect of Betaine-Homocysteine Homeostasis on Oxidative Stress, Inflammation and Apoptosis in Ethanol-Induced Ulcer Model Journal: J Invest Surg. 2022 Nov-Dec;35(11-12):1806-1817.
• Evaluation of the therapeutic effects of calcium dobesilate in sciatic nerve crush injury in rats Journal: Injury. 2022 Nov;53(11):3624-3635.
• PCOS model: Apoptotic changes and role of vitamin D Journal: Azhar A, Naseem Z, Haider G, Farooqui N, Farhat S, Rehman R. PCOS model: Apoptotic changes and role of vitamin D. Electron J Gen Med. 2022;19(5):em398.
• Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate Journal: J Trace Elem Med Biol. 2023 Dec;80:127315.
• Hexagonal Boron Nitride Nanoparticles Prevent Neurodegeneration in Septic Rat Brain Journal: Çakır Gündoğdu A. , Kar F. Hexagonal Boron Nitride Nanoparticles Prevent Neurodegeneration in Septic Rat Brain. Osmangazi Tıp Dergisi. 2023; 45(5): 678-688.

Supplier: BT-Labs