Beschreibung
Overview:
Clonality: Polyclonal
Host: Rabbit
Reactivity:Human, Mouse, Rat
Applications: WB, ELISA
Storage: -20°C for one year
Concentration: 1 mg/ml
Detailed Information:
RGS14 encodes a member of the regulator of G-protein signaling family. Regulator of G-protein signaling 14 contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Antibody Production Information:
The antiserum was produced against synthesized peptide derived from human RGS14. AA range:125-174
Target:
Target: RGS14
Synonyms: RGS14; Regulator of G-protein signaling 14; RGS14
Supplier: BT-Labs